Now showing items 1-6 of 6
Global chromatin compaction in response to ultraviolet radiation
Chromatin, the complex of DNA, associated proteins, and RNA has several levels of folding. Gene expression, DNA replication, and DNA repair are cellular functions dependent on unfolding compacted chromatin. This study ...
Optimizing a Pre-Clinical Mouse Model for Cancer Chemotherapy: Thirty-two Fold Increase in Maximum Tolerated Dose for a Novel Amidoxime with Anti-Cancer Properties
Chemotherapy treatment often follows tumor removal, with goals of preventing regrowth or metastasis from remaining cancerous cells. Our laboratory uses a mouse model for breast cancer chemotherapy, treating with novel ...
A Novel Anti-Cancer p300 Inhibitor Downregulates Cell Cycle Checkpoint Genes in Human Breast Cancer Cells
A novel bis-amixodime, JJMB9, developed by Drs Johnson and Bergel, was recently patented through TWU for its anti-cancer properties, both in cell culture and in vivo using a mouse mammary cancer model. This study ...
Anti-proliferative Effects of Lentinan, a Beta-glucan from Shiitake Mushroom (Lentinula edodes)
Cancer is one of the most significant health challenges worldwide. Lentinan, a betaglucan from shiitake mushroom, Lentinula edodes, has been demonstrated to have an inhibitory effect on selected cancer cells but results ...
Optimizing a Pre-Clinical Mouse Model for Breast Cancer Chemotherapy: Establishing the Minimum Amount of 4T1 Cells Needed for Tumor Formation
We are investigating the effect of a novel anti-cancer amidoxime drug (JJMB9) in a mouse model. To induce tumors for this study, 4T1 mouse mammary carcinoma cells, which are highly malignant and metastatic, are injected ...
The effect of UVB on chromatin condensation in different cell lines
Previous studies in our lab have shown that UV radiation causes chromatin compaction in the nucleus. This study evaluated the UVB-induced DNA condensation and how it varies among different cell lines. We examined on human ...