Effects of a diet rich in Vitamin E on serum vascular endothelial growth factor in healthy adults
Cluff, Brenda Malone
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Studies indicate that Vitamin E may downregulate vascular endothelial growth factor (VEGF), one of several factors involved in angiogenesis. Regulation and expression of VEGF may have implications in both exacerbation of atherosclerotic heart disease and therapy in ischemic heart disease. In the current study, plasma VEGF levels were measured at baseline and after four weeks in healthy individuals who consumed a diet providing 15mg of vitamin E. Simple Effects Analysis was used to compare baseline and intervention VEGF levels against controls. A significant difference (p<0.001) was found in VEGF levels after four weeks of intervention compared to controls, with a 17% (on average) decrease in VEGF concentration in the experimental group. This study shows that dietary vitamin E decreases serum VEGF concentration in healthy adults, independent of serum lipid levels.